Title: Enhanced I H Depresses Rat Entopeduncular Nucleus Neuronal Activity from High Frequency Stimulation or Raised K Running Title: I H Channel Enhancement Depresses Basal Ganglia Neuronal Activity

Neurophysiol D . S . Shin and P . L . Carlen + eRaised K Neuronal Activity From High - Frequency Stimulation or Depresses Rat Entopeduncular Nucleush I Enhanced

Decoupling neuronal oscillations during subthalamic nucleus stimulation in the parkinsonian primate.

Subthalamic nucleus (STN) stimulation is a popular treatment for Parkinson's disease; however, its effect on neuronal activity is unclear. We performed simultaneous multi-electrode recordings in the STN and its targets, the globus pallidus internus (GPi) and externus (GPe) in the parkinsonian non-human primate during high frequency STN macro-stimulation. Our results indicate that in the parkins...

Subthalamic nucleus functional organization revealed by parkinsonian neuronal oscillations and synchrony.

The emergence of oscillations and synchrony among neurons of the basal ganglia is a well-known characteristic of Parkinson's disease. In this study we used intra-operative microelectrode recording to investigate this interrelationship between these two phenomena in the subthalamic nucleus (STN) neurons of 39 human Parkinson's disease patients undergoing deep brain stimulation surgery. From the ...

Intrastriatal mesencephalic grafts affect neuronal activity in basal ganglia nuclei and their target structures in a rat model of Parkinson's disease.

Nigrostriatal dopamine (DA) lesions lead to changes of neuronal activity in basal ganglia nuclei such as the globus pallidus (GP, the rodent homolog of lateral globus pallidus), entopeduncular nucleus (EP, the rodent homolog of medial globus pallidus), substantia nigra pars reticulata (SNR), and subthalamic nucleus (STN). We investigated in rats whether embryonic mesencephalic DA neurons grafte...

Dual effect of high-frequency stimulation on subthalamic neuron activity.

Although it is well known that high-frequency stimulation (HFS) of the subthalamic nucleus (STN) alleviates the cardinal symptoms of Parkinson's disease, the underlying mechanisms are not fully understood. We investigated the effect of stimulation from low to high frequencies on rat STN neurons in naive and dopamine-depleted slices using whole-cell, current-clamp techniques and on-line artifact...